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Herpes Simplex Virus Type 1 (HSV-1) DNA Detection by Nucleic Acid Probe (Genital Sample)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of herpes simplex virus type 1 (HSV-1) genetic material in a sample taken from genital areas, often to diagnose genital herpes infection.

Quick summary

["A simple test to help determine if you have HSV-1, which can cause genital sores and outbreaks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
80354-4
Short code
HSV 1+2 DNA Pnl Anogenital NAA+probe
Synonyms
HSV 1+2 DNA Pnl Anogenital NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like sores, blisters, or pain in the genital area, or if you have a history of genital herpes. It can also be used to confirm a diagnosis when symptoms are unclear or during asymptomatic periods to check for active infection.

What to Expect Before the Test

No special preparation is needed. You may be asked to clean the genital area gently with mild soap and water before providing a sample. The test involves collecting cells from the affected area using a swab.

How the Test Works

The sample is analyzed in a lab to detect the genetic material (DNA) of HSV-1 using a specialized probe. This method is highly sensitive and can identify the virus even when symptoms are not present.

What the Results Mean

A positive result indicates the presence of HSV-1 DNA, suggesting an active infection. A negative result means the virus was not detected in the sample at the time of testing. Results can help guide treatment and management plans.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is crucial for diagnosing genital herpes caused by HSV-1, which can lead to recurrent outbreaks, discomfort, and potential complications if untreated. Early diagnosis allows for appropriate treatment to manage symptoms, reduce transmission risk, and support overall health.

Short name

HSV-1 DNA Genital Probe Test

Frequently asked questions

How often can I get tested for HSV-1?
You may need to be tested multiple times if you have symptoms or if you are unsure about your infection status. Testing can also be done during asymptomatic periods if there is a high suspicion of infection, such as after exposure or during outbreaks.
What are the typical symptoms of HSV-1 infection?
Common symptoms include painful or itchy sores, blisters, or ulcers in the genital area, lower abdomen, or buttocks. Some people may also experience flu-like symptoms such as fever, swollen lymph nodes, or body aches. However, many individuals with HSV-1 have no symptoms or mild symptoms.
Can HSV-1 be transmitted through oral sex?
Yes, HSV-1 can be transmitted through oral sex. It is important to note that the virus can be present in saliva even when there are no visible sores, so it’s best to avoid oral contact with anyone who has active herpes lesions to reduce the risk of transmission.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy