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Herpes Simplex Virus Type 1 DNA (Quantitative) in Saliva by Nucleic Acid Probe

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of genetic material from the herpes simplex virus type 1 (HSV-1) in your saliva. It helps determine if you have an active infection or have been exposed to the virus.

Quick summary

["This test helps assess whether HSV-1 is active in your mouth or saliva, which can inform treatment decisions or monitor infection status."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
92863-0
Short code
HSV 1+2 DNA Pnl Skin NAA+probe
Synonyms
HSV 1+2 DNA Pnl Skin NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like cold sores, recurrent oral ulcers, or if you’ve been exposed to someone with HSV-1. It can also be used for research or screening in certain clinical settings.

What to Expect Before the Test

No special preparation is needed. You’ll provide a saliva sample, often collected by swabbing the inside of your cheek. The sample is then analyzed in a lab to detect viral DNA.

What the Test Results Mean

A positive result means HSV-1 DNA is present in your saliva, indicating an active infection or recent exposure. A negative result suggests no detectable viral DNA at the time of testing.

Common Causes of Positive Results

Active herpes outbreaks (cold sores), recent viral shedding (even without symptoms), or exposure to the virus can lead to a positive result. Chronic carriers may also test positive.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 Saliva DNA Test

Frequently asked questions

How often should I get this test if I have recurrent cold sores?
If you have frequent cold sores, your doctor may recommend testing during outbreaks or periodically to monitor viral activity. Results can help adjust treatment or identify triggers.
Can this test be used to diagnose HSV-1 in people without symptoms?
Yes, but it’s not typically used for routine screening in asymptomatic individuals. It’s more useful in research, outbreak investigations, or when symptoms are suspected but not present.
What if my test results are positive but I don’t have symptoms?
A positive result could mean you’re shedding the virus asymptomatically. Your doctor may recommend antiviral treatment to reduce transmission or monitor for future outbreaks.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy