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Herpes Simplex Virus Type 1 DNA (Serum/Plasma) by Nucleic Acid Amplification Probe

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of genetic material from Herpes Simplex Virus Type 1 (HSV-1) in your blood, which may help assess infection status or guide treatment decisions.

Quick summary

["This test helps identify if HSV-1 DNA is present in your blood, potentially aiding in monitoring infection or evaluating antiviral therapy."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47409-8
Short code
HSV1+2 DNA # SerPl NAA+probe
Synonyms
HSV1+2 DNA # SerPl NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for the genetic material (DNA) of HSV-1, a virus that can cause cold sores or other infections. This DNA is detected using a specialized probe that targets specific viral sequences.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms of HSV-1 infection, if you’re at risk for reactivation, or if you’re undergoing treatment to manage the virus.

What to Expect Before the Test

No special preparation is needed. A blood sample will be drawn from a vein, similar to other routine blood tests. The sample is processed to detect HSV-1 DNA in the serum or plasma.

What the Results Mean

Positive results indicate the presence of HSV-1 DNA in your blood, suggesting active infection or viral shedding. Negative results mean no detectable viral DNA was found at the time of testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 DNA Test

Frequently asked questions

How often should I expect this test?
The frequency depends on your medical needs. Your healthcare provider will determine if repeat testing is necessary, such as during treatment or if symptoms recur.
Does this test show if I have had HSV-1 before?
No, this test specifically measures active HSV-1 DNA in your blood. It does not indicate past infection unless combined with antibody tests, which detect immune responses.
Can I take antiviral medications before the test?
Yes, you can take antiviral medications as prescribed. However, inform your healthcare provider before the test to ensure accurate results, as some medications may affect viral detection.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy