Skip to content

Herpes Simplex Virus Type 1 (HSV-1) DNA Detection by Nucleic Acid Amplification Probe

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of Herpes Simplex Virus Type 1 (HSV-1) genetic material in your urine using a special probe to detect viral DNA.

Quick summary

["Assesses active herpes infection in the urinary tract."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49383-3
Short code
HSV1+2 DNA # Ur NAA+probe
Synonyms
HSV1+2 DNA # Ur NAA+probe
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like frequent urination, pain or burning during urination, or if you suspect a urinary tract infection (UTI) caused by HSV-1. It can also be used to confirm a diagnosis in certain clinical situations or monitor treatment response.

What to Expect Before the Test

No special preparation is needed. You’ll provide a urine sample, typically collected in the morning. Avoid using urinary tract medications or certain hygiene products for 24 hours before testing if instructed by your provider.

What the Test Involves

A sterile urine sample is collected and sent to a lab. The lab uses a specialized technique to detect HSV-1 DNA fragments. This process is highly sensitive and can identify even small amounts of virus.

What the Results Mean

A positive result indicates the presence of HSV-1 DNA in your urine, suggesting active infection. A negative result means no detectable viral DNA was found in this sample. Results should be interpreted by your healthcare provider in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 DNA in Urine

Frequently asked questions

How is this test different from a herpes antibody test?
This test detects the virus itself (HSV-1 DNA) in your urine, which shows active infection. An antibody test detects your immune system’s response to past or current infection, not the virus directly. They serve different purposes in diagnosis and monitoring.
What if I have recurring urinary symptoms but no history of herpes?
If you have recurring urinary symptoms, your provider may order this test to rule out HSV-1 infection. Other causes like bacterial infections or interstitial cystitis should also be considered. Treatment may involve antiviral medications if HSV-1 is confirmed.
Can I still have HSV-1 if my urine test is negative?
Yes, HSV-1 can be present in other body fluids (like saliva or genital secretions) even if it’s not detected in urine. Test results should be discussed with your healthcare provider to determine the best next steps for your situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy