Skip to content

Herpes Simplex Virus Type 1 (HSV-1) Immunoglobulin G Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures your body’s immune response to herpes simplex virus type 1 (HSV-1), a common virus that can cause cold sores or other infections. It helps determine if your immune system has ever been exposed to HSV-1.

Quick summary

["This test assesses past exposure to HSV-1 through antibodies, not current infection status."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13249-8
Short code
HSV1+2 IgG CSF-aCnc
Synonyms
HSV1+2 IgG CSF-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of HSV-1 infection (like cold sores), a history of cold sores, or if you’re evaluating immune function. It can also be part of a broader evaluation for conditions linked to viral exposure.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample from a vein in your arm. The test is typically done in a lab setting and results are ready within a few days to a week, depending on the lab.

What the Results Mean

If your results are positive, it means your immune system has produced antibodies against HSV-1, indicating past exposure. A negative result suggests no detectable antibodies, meaning either no prior exposure or insufficient immune response to detect.

Common Reasons for Testing

This test is often used to confirm past infection rather than diagnose active disease. It can also be part of research studies or investigations into immune responses to viruses.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 IgG Antibody

Frequently asked questions

How long will it take to get my results?
Results are usually available within 5 to 14 business days, depending on your lab’s processing time. Your healthcare provider will contact you directly with your results.
Can I have this test if I’m currently sick with a cold sore?
Yes, you can. This test measures antibodies from past exposure and does not directly indicate whether you have an active infection. If you have symptoms, your provider may also recommend other tests.
Does this test show if I have an active HSV-1 infection?
No, this test does not detect active HSV-1 infection. For that, you would need a different test, such as a viral load or HSV culture, which checks for the virus itself in your body.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy