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Herpes Simplex Virus Type 1 Immunoglobulin G Antibody (Serum) - Confirmatory

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies to herpes simplex virus type 1 (HSV-1) in your blood. These antibodies indicate past infection with HSV-1, which can cause cold sores or other symptoms.

Quick summary

["Past HSV-1 infection may affect future health, including potential risks for certain neurological conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31411-2
Short code
HSV1+2 IgG Ser-aCnc
Synonyms
HSV1+2 IgG Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms of HSV-1 infection (like cold sores), if you’ve been exposed to someone with HSV-1, or if you have a history of recurrent cold sores. It can also help confirm a diagnosis when other tests are inconclusive.

What to Expect During the Test

A blood sample will be drawn from a vein in your arm. You may feel a slight pinch, but it usually takes only a few minutes. You can eat and drink normally before the test.

How the Results Are Interpreted

Positive results mean you likely had HSV-1 at some point in your life. Negative results suggest you either haven’t been infected or the test was taken too early after exposure. Results don’t indicate current infection status.

What It Means for Your Health

While this test confirms past exposure, it doesn’t affect your current health risks. HSV-1 can remain dormant and may reactivate later, potentially causing cold sores or other symptoms. Your provider may recommend monitoring or preventive measures if needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 IgG Antibody Confirmation

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 2–5 business days, depending on your lab’s processing time.
Can I have a sample drawn if I’m currently experiencing cold sores?
Yes, but your provider may recommend additional testing (like HSV-1 PCR) to check for active infection while you’re symptomatic.
Does this test show if I’m currently contagious?
No, this test only detects past infection. Active contagiousness is determined by symptoms, viral load, or other diagnostic tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy