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Herpes Simplex Virus Type 1 Immunoglobulin G (IgG) Antibody, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of antibodies your body produces in response to exposure to the herpes simplex virus type 1 (HSV-1), which causes cold sores and can also affect other parts of the body.

Quick summary

["This test helps determine past exposure to HSV-1 and whether your immune system has developed immunity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63432-9
Short code
HSV1+2 IgM CSF-aCnc
Synonyms
HSV1+2 IgM CSF-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms of HSV-1 infection, such as cold sores, or if you have a history of recurrent cold sores. It may also be used to assess immune response in certain medical conditions or during research studies.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into a vein in your arm to draw a blood sample. This process is quick and usually causes only a minor sting.

What the Test Results Mean

Positive results indicate the presence of HSV-1 IgG antibodies, suggesting past exposure to the virus. However, this does not confirm an active infection. If you have symptoms, additional testing may be needed to diagnose an active HSV-1 infection.

Common Reasons for Testing

This test is often used in research settings, epidemiological studies, or to evaluate immune status in individuals with suspected or known exposure to HSV-1.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-1 IgG Antibody

Frequently asked questions

How accurate is this test?
This test is generally reliable for detecting past exposure to HSV-1. However, it cannot distinguish between past infection and current infection. False positives or negatives can occur due to various factors, including cross-reactivity with other viruses or laboratory errors.
Can this test be used to diagnose an active HSV-1 infection?
No, this test alone cannot diagnose an active HSV-1 infection. If you suspect an active infection, your healthcare provider may recommend additional tests, such as viral culture or PCR testing.
What does a high or low level of HSV-1 IgG antibodies indicate?
A high level of HSV-1 IgG antibodies suggests past exposure and likely immunity, but it does not guarantee protection from future infections. A low or undetectable level may indicate no prior exposure or a compromised immune response to HSV-1.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy