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Herpes Simplex Virus Type 1 IgG Antibody, Serum (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of antibodies your body produces in response to the herpes simplex virus type 1 (HSV-1), which can cause cold sores or oral herpes.

Quick summary

["IgG antibodies help your immune system recognize and fight past infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43030-6
Short code
HSV1+2 IgM Ser-aCnc
Synonyms
HSV1+2 IgM Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

This test detects IgG antibodies specific to HSV-1, which your immune system creates after exposure to the virus. Unlike IgM antibodies (which appear shortly after infection), IgG antibodies persist longer, indicating a past infection or immunity.

Why Might You Need This Test?

Doctors may order this test if you have symptoms of HSV-1 (like cold sores) or if you have a history of recurrent infections. It can also help assess immunity in individuals exposed to the virus.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The serum portion is then analyzed using an immunoassay method to measure IgG antibody levels.

What Are Possible Results?

A positive result suggests you have developed IgG antibodies, meaning you likely had HSV-1 at some point. A negative result means no detectable IgG antibodies were found in this sample.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A positive IgG result does not confirm an active infection but indicates past exposure. If you have symptoms or recurrent outbreaks, your doctor may recommend additional testing (like IgM or viral culture) to diagnose active herpes. This test is useful for monitoring immunity in high-risk individuals.

Short name

IgG Antibody to HSV-1

Frequently asked questions

What Does a Positive Result Mean?
A positive result means your body has produced antibodies against HSV-1, suggesting you’ve been exposed to the virus at some point. This does not indicate whether you currently have an active infection.
Can This Test Detect an Active Infection?
No, this test specifically measures IgG antibodies, which appear after an initial infection. For diagnosing an active herpes outbreak, your doctor may use different tests (like IgM or viral culture).
How Long Do IgG Antibodies Last?
IgG antibodies can remain in your system for years after infection, sometimes even for life. However, their levels may change over time, so repeat testing is not typically recommended unless advised by your doctor.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy