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Herpes Simplex Virus Type 1 Immunoglobulin G (IgG) Antibody, Titration (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies against Herpes Simplex Virus Type 1 (HSV-1) in your blood. Antibodies are proteins your immune system makes to help fight infections.

Quick summary

["This test helps determine if you’ve ever been exposed to HSV-1, which can cause cold sores or other infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49731-3
Short code
HSV1+2 IgM Titr CSF IF
Synonyms
HSV1+2 IgM Titr CSF IF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms like cold sores, recurrent mouth ulcers, or if you’ve been exposed to someone with HSV-1. It can also be used to monitor immune response or diagnose certain conditions linked to HSV-1 exposure.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. The sample is collected in a tube and sent to a lab for testing.

What the Test Results Mean

A positive result means you have detectable HSV-1 IgG antibodies, indicating past exposure to the virus. A negative result suggests no current detectable antibodies, but this doesn’t always mean you’ve never been exposed.

Common Reasons for Testing

This test is often used to confirm past infection, assess immune function, or investigate symptoms like recurrent cold sores. It’s not typically used to diagnose active infections, which are usually managed with different tests or clinical evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 IgG Antibody

Frequently asked questions

What does a positive result mean?
A positive result means your immune system has recognized and produced antibodies against HSV-1. This suggests you’ve likely had past exposure, but it doesn’t confirm whether you’re currently infected or experiencing symptoms. Active infections are usually diagnosed with different tests or clinical signs.
Can this test detect active herpes infections?
No, this test specifically measures antibodies, which indicate past exposure. Active herpes infections are typically diagnosed through viral culture, PCR testing, or clinical evaluation of symptoms like sores or lesions.
How long do HSV-1 IgG antibodies last?
HSV-1 IgG antibodies usually remain in the blood for life after initial infection. However, their levels may fluctuate over time, and they don’t always correlate with current immune function or risk of reactivation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy