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Herpes Simplex Virus Type 1 Antibody, Qualitative (IgG) by Probe-Based Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the herpes simplex virus type 1 (HSV-1), which can help identify past infection or immunity.

Quick summary

["Checks for immunity to HSV-1, a common virus that can cause cold sores or other infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
92849-9
Short code
HSV 1 + 2 + VZV DNA Pnl CSF NAA+probe
Synonyms
HSV 1 + 2 + VZV DNA Pnl CSF NAA+probe
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms of HSV-1 infection (e.g., cold sores, recurrent mouth sores) or if you’re at higher risk for infection (e.g., newborns, immunocompromised individuals). It may also be used to confirm previous exposure or assess immunity before certain procedures.

What to Expect Before the Test

No special preparation is needed. The test is typically done on a blood sample drawn from a vein. If you’re concerned about discomfort, let your provider know.

What the Test Results Mean

Positive results indicate the presence of HSV-1 antibodies, suggesting past infection or immunity. Negative results mean no detectable antibodies were found at this time. Results alone don’t confirm active infection—symptoms or other testing may be needed.

Common Misconceptions

This test does not diagnose active HSV-1 infection. It only measures antibodies, which can linger long after the virus has cleared. If you suspect an active outbreak, consult your provider for additional evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-1 Antibody Test (IgG)

Frequently asked questions

What symptoms might this test be used for?
Symptoms like recurrent cold sores, painful mouth sores, or unusual rashes in areas like the genitals or eyes may prompt this test, especially if other causes (like herpes simplex virus type 2) are suspected. It’s also used in newborns to rule out congenital HSV infection.
How does this test differ from an HSV-1 PCR test?
This test detects antibodies (IgG) produced by your immune system after infection, while an HSV-1 PCR test looks for the virus itself in a sample (e.g., saliva or swab). Antibody tests are useful for past exposure, whereas PCR tests identify active infection.
Can this test be used to prevent HSV-1?
No, this test does not prevent HSV-1. It helps assess immunity or past exposure. If you’re at risk for infection, your provider may recommend preventive measures like antiviral medications or good hygiene practices.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy