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Herpes Simplex Virus Type 1 Antibody, Qualitative (IgG) by Probe-Based Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the herpes simplex virus type 1 (HSV-1), which can help determine past exposure to the virus that causes cold sores.

Quick summary

["This test helps identify if your body has ever been exposed to HSV-1, a common virus linked to cold sores."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
107908-6
Short code
HSV 1 + 2 + VZV DNA Pnl Spec NAA+probe
Synonyms
HSV 1 + 2 + VZV DNA Pnl Spec NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects specific antibodies (IgG) produced by your immune system in response to HSV-1. These antibodies indicate that your body has encountered the virus at some point, even if you don’t currently have symptoms.

Why It’s Done

Doctors may order this test if you have a history of cold sores, recurrent oral lesions, or if you’re being evaluated for conditions where HSV-1 exposure could be relevant, such as certain immune-related disorders.

How the Test Works

A small blood sample is taken from your arm. The sample is then analyzed using a probe-based immunoassay to detect the presence of HSV-1 antibodies. This method is highly sensitive and specific for identifying past infection.

What to Expect Before the Test

No special preparation is needed. You may have a slight bruise or soreness at the injection site, but this usually fades quickly. If you’re on blood-thinning medication, let your healthcare provider know before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results suggest past exposure to HSV-1, meaning your immune system has likely cleared the virus. This can be useful for monitoring immune function, diagnosing certain conditions, or guiding treatment decisions in specific clinical scenarios. However, a positive result does not confirm active infection—active HSV-1 infection would require additional testing.

Short name

HSV-1 Antibody (IgG) Qualitative

Frequently asked questions

What Does a Positive Result Mean?
A positive result means your body has produced antibodies against HSV-1, indicating past exposure. This does not necessarily mean you’re currently infected or have active symptoms. It simply shows your immune system has recognized and responded to the virus.
What Does a Negative Result Mean?
A negative result means your blood sample did not detect HSV-1 antibodies at the time of testing. This could mean you’ve never been exposed to HSV-1, or if you have been, the infection may have cleared before your immune system produced detectable antibodies.
Does This Test Differentiate Between HSV-1 and HSV-2?
No, this test only detects antibodies specific to HSV-1. To distinguish between HSV-1 and HSV-2, additional testing (such as HSV-2 antibody testing) would be required.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy