Herpes Simplex Virus Type 1 (HSV-1) Antibody, Qualitative, Viral DNA Probe
This test detects antibodies to Herpes Simplex Virus Type 1 (HSV-1), a common virus that can cause cold sores and other infections. It helps determine if your body has been exposed to HSV-1.
["This test checks for past exposure to HSV-1, not whether you currently have an active infection."]
Key facts at a glance
- LOINC
- 104651-5
- Short code
- HSV 1 + 2 + VZV+T pall pnl NAA+probe
- Synonyms
- HSV 1 + 2 + VZV+T pall pnl NAA+probe
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- probe-amp-tar
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
This test is done to find out whether you have been infected with the herpes simplex virus, known as HSV. It helps your healthcare provider confirm a diagnosis when you have symptoms such as sores, or when you may have been exposed to the virus through close contact with an infected person.
Doctors may order this test if you have symptoms like cold sores, recurrent mouth ulcers, or if you’ve been exposed to someone with HSV-1. It can also be used to confirm a diagnosis in certain clinical scenarios or for research purposes.
Before the test, tell your healthcare provider about any medicines you take and any allergies you have. If a sore is being swabbed, avoid applying creams or ointments to the area beforehand. If a blood sample is needed, no fasting or special preparation is usually required, and you can eat and drink normally.
No special preparation is needed. The test typically involves a blood draw from a vein in your arm. If you’re concerned about discomfort, let your healthcare provider know.
Your results show whether herpes simplex virus or antibodies against it were found in your sample. A positive result suggests a current or past HSV infection, while a negative result may mean no infection was detected. Very recent infections can sometimes be missed, so your provider may recommend repeat testing if symptoms continue.
A positive result means your body has produced antibodies against HSV-1, indicating past exposure. A negative result suggests you either haven’t been exposed or the test was done too early after exposure. Results are qualitative (yes/no) and don’t provide a timeline of infection.
Testing is often recommended if you have blisters, sores, itching, or unusual symptoms in the genital or oral area, if a current or past partner has herpes, if you are pregnant and at risk, or if your provider wants to determine which virus type, HSV-1 or HSV-2, is present.
This test is often used to diagnose HSV-1 infection in cases where symptoms are unclear or to assess immune response in research or clinical studies. It’s not typically used for routine screening.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
HSV-1 Antibody Test (Qualitative)
Frequently asked questions
This test helps confirm a diagnosis of past HSV-1 infection, which can be important for managing symptoms, preventing spread, or planning further medical evaluation. It’s not used to diagnose active infection, which would require different testing methods.
A positive result means your immune system has recognized HSV-1, likely from past exposure. This doesn’t indicate whether you currently have an active infection, which would require additional testing.
No, this test only detects antibodies, which appear after your body has been exposed to HSV-1. For diagnosing an active outbreak, your doctor may recommend a different test or viral culture.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy