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Herpes Simplex Virus 1 Antibody, Qualitative (IgG) in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of antibodies against Herpes Simplex Virus 1 (HSV-1), a common virus that can cause cold sores and other infections.

Quick summary

["It helps determine if your immune system has encountered HSV-1, which may affect future infection risk or symptoms."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44470-3
Short code
HSV1 Ag Anal Ql
Synonyms
HSV1 Ag Anal Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86038
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects IgG antibodies specific to HSV-1, indicating past exposure to the virus. These antibodies are produced by your immune system in response to infection and can remain in your blood for years. This test is qualitative, meaning it only tells you whether antibodies are present or not, without providing a quantitative measure of their level.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms suggestive of HSV-1 infection (such as cold sores), if you have a history of recurrent cold sores, or if you are being evaluated for conditions where HSV-1 exposure could be relevant (e.g., certain immune disorders). It may also be used as part of a broader evaluation for sexually transmitted infections.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood sample drawn from a vein in your arm, similar to other blood tests. If you are taking blood thinners or have a history of bleeding disorders, inform your healthcare provider beforehand.

What to Expect During the Test

The blood sample is collected and sent to a laboratory for analysis. The test uses an immunoassay method to detect the presence of HSV-1 antibodies. Results are typically available within a few days.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 Antibody Screen

Frequently asked questions

Does this test show if I currently have an active HSV-1 infection?
No, this test only detects antibodies produced by your immune system in response to past exposure to HSV-1. To diagnose an active infection, your healthcare provider may use other methods, such as viral culture or PCR testing.
Can I get HSV-1 from this test?
No, the test involves only blood collection and does not involve any risk of transmitting HSV-1. The procedure is safe and sterile.
What does it mean if my test is negative?
A negative result means that detectable HSV-1 antibodies were not found in your blood. This could mean you have never been exposed to HSV-1, but it also does not rule out past exposure if the antibodies have already cleared from your system.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy