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Herpes Simplex Virus Type 1 Antibody, IgG (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against herpes simplex virus type 1 (HSV-1), a common virus that can cause cold sores and, rarely, more severe infections.

Quick summary

["Detects past exposure to HSV-1, helping identify immunity status."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44472-9
Short code
HSV1 Ag Eye Ql
Synonyms
HSV1 Ag Eye Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of cold sores, recurrent infections, or if you’re considering preventive measures against HSV-1. It can also be used to assess immunity in certain medical or research contexts.

What to Expect During Testing

A blood sample is drawn from a vein in your arm. The sample is then sent to a lab for analysis using an immunoassay method to detect HSV-1 antibodies. Results are typically available within a few days.

Understanding Your Results

A positive result indicates the presence of HSV-1 antibodies, suggesting past infection and potential immunity. A negative result means no detectable antibodies, but this doesn’t rule out current infection. Consult your healthcare provider for interpretation.

Clinical Significance

While this test confirms past exposure to HSV-1, it does not diagnose active infection. Active HSV-1 infections are usually identified through symptoms like sores or by testing for viral DNA/RNA. Antibody levels can also be monitored in some research or clinical studies to track immune response.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Antibody to HSV-1

Frequently asked questions

What does a positive result mean?
A positive result means your body has produced antibodies against HSV-1, indicating you likely had the virus at some point and may have immunity. However, you could still experience outbreaks.
Can this test detect active herpes infection?
No, this test only detects antibodies, which indicate past infection. Active herpes is diagnosed through symptoms or other specific tests for viral presence.
Is this test the same as a cold sore test?
No, this test is for antibodies to HSV-1, which can indicate immunity from past infection. A cold sore test would involve checking for active viral DNA or symptoms rather than antibodies.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy