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Herpes Simplex Virus 1 Antibody (IgG) in Saliva – Screening Test

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the herpes simplex virus type 1 (HSV-1) in your saliva. Antibodies indicate past exposure to the virus, which can cause cold sores.

Quick summary

["A positive result suggests you may have been exposed to HSV-1, but it doesn’t confirm active infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44474-5
Short code
HSV1 Ag Throat Ql
Synonyms
HSV1 Ag Throat Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects IgG antibodies produced by your immune system in response to HSV-1. These antibodies are present after initial infection and can linger for years. This screening is not used to diagnose active herpes outbreaks but helps assess past exposure.

Why It Might Be Ordered

Your healthcare provider may order this test if you have a history of cold sores, recurrent oral lesions, or if you’re being evaluated for immune-related conditions that could affect viral responses.

What to Expect Before the Test

No special preparation is needed. You’ll provide a saliva sample, often collected by swabbing the inside of your cheek or using a saliva collection device.

What the Results Mean

A positive result means your body has produced antibodies to HSV-1, indicating past exposure. A negative result suggests no detectable antibodies at the time of testing. Results alone don’t confirm active infection or the severity of past exposure.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-1 IgG Saliva Screen

Frequently asked questions

Why might this test be important?
This test helps determine if you’ve been exposed to HSV-1, which can inform decisions about immune health, potential transmission risks, or underlying conditions affecting your immune response.
How does this differ from a cold sore diagnosis?
This test does not diagnose active herpes outbreaks. If you have symptoms like sores or pain, you may need additional testing or evaluation by a healthcare provider.
What if I have recurring cold sores?
Recurrent cold sores are common and often linked to HSV-1. While this test confirms past exposure, ongoing symptoms may require further evaluation to understand triggers or underlying causes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy