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Herpes Simplex Virus Type 1 Antibody, Tissue-Specific (IgG) by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to Herpes Simplex Virus Type 1 (HSV-1) in your blood, which helps identify past infection with the virus responsible for cold sores and oral herpes.

Quick summary

["This test helps determine if you’ve been exposed to HSV-1, even if you don’t currently have symptoms."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44475-2
Short code
HSV1 Ag Tiss Ql
Synonyms
HSV1 Ag Tiss Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you have recurring cold sores, a history of oral herpes, or if you’re being evaluated for conditions linked to HSV-1 exposure, such as certain neurological or ocular infections. It can also be used in research or clinical trials related to HSV-1.

What to Expect During the Test

A blood sample is drawn from a vein, typically in your arm. The process is quick and usually painless. You may feel a slight pinch, but it only takes a few minutes. No special preparation is needed.

How the Results Are Interpreted

Positive results indicate the presence of HSV-1 antibodies, suggesting past infection. Negative results mean no detectable antibodies were found at this time. Interpretation depends on clinical context, such as your symptoms or medical history.

What the Results Mean for You

If you test positive, you’ve likely had HSV-1 at some point, which is common. If you test negative, it doesn’t rule out past exposure—antibodies may take time to develop. Follow-up with your healthcare provider for guidance tailored to your situation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-1 Antibody (IgG) - Tissue-Specific

Frequently asked questions

What symptoms might this test help diagnose?
This test primarily helps confirm past HSV-1 infection rather than current active disease. It’s not used to diagnose active herpes outbreaks but can be useful in certain research or clinical scenarios to assess exposure history.
How long does it take to get results?
Results are typically available within 24 to 72 hours, depending on lab processing times. Your healthcare provider will contact you once the results are ready.
Can I get HSV-1 from this test?
No, this test involves only blood sampling and does not pose any risk of viral transmission. Blood samples are handled with strict safety protocols to prevent contamination.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy