Herpes Simplex Virus Type 1 Antibody, IgG (Serum or Plasma)

This test is done to find out whether you have been infected with herpes simplex virus (HSV), which can cause oral or genital sores. Your doctor may order it if you have symptoms, if you have had contact with someone who has herpes, or as part of evaluating your overall sexual health.

Doctors may order this test if you have symptoms like cold sores, recurrent mouth ulcers, or if you’ve been exposed to someone with HSV-1. It can also be used in research or to monitor immune responses in certain conditions.

Little preparation is usually needed before this test. If a blood sample will be drawn, you can normally eat and drink as usual. Tell your doctor about any medications or supplements you take, and if a sore will be swabbed, avoid applying creams or ointments to the area before your visit.

No special preparation is needed. A blood sample is typically taken from a vein in your arm. If you’re concerned about needles, let your healthcare provider know.

A positive result means that signs of HSV infection were found in your sample. A negative result usually means no infection was detected, but testing too soon after exposure can sometimes miss an infection. Your doctor will explain what your specific result means and whether repeat testing might be needed.

Positive results indicate you’ve likely had HSV-1 at some point, meaning your immune system has produced antibodies to fight it. Negative results suggest you may not have been exposed or haven’t developed antibodies yet.

This test is generally very safe. If your blood is drawn, you may feel a quick sting, and mild bruising or soreness at the needle site can occur. If a sore is swabbed, you may feel brief discomfort. Serious side effects are rare, and any mild symptoms usually go away on their own.

The most common side effect is a slight bruise or slight pain at the needle site. Rarely, there may be swelling or redness.