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Herpes Simplex Virus Type 1 Antibody, IgG (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the herpes simplex virus type 1 (HSV-1), which can help identify past infection with this virus.

Quick summary

["This test helps determine if you’ve ever been exposed to HSV-1, even if you don’t currently have symptoms."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10677-3
Short code
HSV1 Ag Tiss Ql ImStn
Synonyms
HSV1 Ag Tiss Ql ImStn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immune-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have concerns about past exposure to HSV-1, such as recurrent cold sores, family history of HSV-1, or if you’re planning pregnancy and want to assess potential risks.

What the Test Measures

The test detects IgG antibodies in your serum. These antibodies develop after your body has encountered HSV-1, usually within weeks to months after infection. They remain in your system long-term and can indicate past exposure.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in your arm. The blood is processed to separate serum, which is then tested for the presence of HSV-1 antibodies.

What the Results Mean

Positive results suggest you have developed antibodies to HSV-1, indicating past infection. Negative results mean no detectable antibodies were found at the time of testing, but this does not rule out past exposure entirely.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

IgG Antibody to HSV-1

Frequently asked questions

What does a positive result mean?
A positive result means your body has produced antibodies against HSV-1, suggesting you have been infected with the virus at some point. This does not mean you currently have an active infection, but it confirms past exposure.
Can this test detect active herpes infection?
No, this test specifically looks for antibodies, which indicate past infection rather than an active outbreak. For diagnosing active herpes, your healthcare provider may recommend other tests or clinical assessment.
How long after infection might antibodies appear?
IgG antibodies typically develop within weeks to months after initial HSV-1 infection. However, timing can vary, and some people may take longer to develop detectable antibodies.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy