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Herpes Simplex Virus Type 1 DNA (Serum/Plasma) Qualitative Probe

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of genetic material from the herpes simplex virus type 1 (HSV-1) in your blood. It helps determine if you have an active infection or if the virus is present in your system.

Quick summary

["This test can help diagnose active HSV-1 infection or assess viral load in certain clinical scenarios."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
62473-4
Short code
HSV1 DNA # BAL NAA+probe
Synonyms
HSV1 DNA # BAL NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for the DNA sequence of HSV-1, which is unique to the virus. If the virus is actively replicating in your bloodstream, its DNA will be detected. This method uses a specialized probe to identify the viral genetic material with high sensitivity.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms suggestive of HSV-1 infection (such as sores, fever, or neurological symptoms), if you have a history of HSV-1 exposure, or if you are being evaluated for conditions linked to viral load monitoring (e.g., certain immunocompromised states).

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The blood is then processed to separate the serum or plasma, which is tested for the presence of HSV-1 DNA. This test does not require fasting.

What to Expect Before the Test

No special preparation is needed. You may experience mild discomfort or bruising at the injection site, but this usually resolves quickly. If you are on blood-thinning medications, inform your provider before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This qualitative test confirms the presence of HSV-1 DNA in your blood, which can indicate an active infection. It is particularly useful in diagnosing HSV-1 in cases where traditional culture methods are less reliable or when monitoring viral load in immunocompromised patients. Results can guide treatment decisions, such as antiviral therapy, and help manage outbreaks or chronic infections.

Short name

HSV-1 DNA Test (Qualitative)

Frequently asked questions

What does a positive result mean?
A positive result means that HSV-1 DNA was detected in your blood sample, suggesting an active infection or the presence of the virus in your system. This does not always correlate with symptoms and may require further evaluation by your healthcare provider.
What does a negative result mean?
A negative result means that HSV-1 DNA was not detected in this sample. However, it does not definitively rule out an infection, especially if the test was taken during a non-active phase. Your provider may recommend retesting or other diagnostic methods if needed.
Can this test be used to determine if I have been exposed to HSV-1?
No, this test specifically detects active HSV-1 infection by looking for viral DNA in your blood. To determine exposure history, other tests such as antibody tests (e.g., HSV serology) are typically used.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy