Herpes Simplex Virus Type 1 (HSV-1) DNA in Whole Blood by Nucleic Acid Amplification (NAA) Probe
This test detects the presence of genetic material from Herpes Simplex Virus Type 1 (HSV-1) in your blood. It helps determine if you have an active infection or if the virus is present in your system.
["This test can help diagnose or monitor HSV-1 infections, though it’s most useful for detecting active viral activity."]
Key facts at a glance
- LOINC
- 49985-5
- Short code
- HSV1 DNA # Bld NAA+probe
- Synonyms
- HSV1 DNA # Bld NAA+probe
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- probe-amp-tar
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test looks for the DNA sequence of HSV-1 in your blood. This DNA is a fragment of the virus’s genetic material. If present, it suggests an active infection or reactivation of HSV-1, which can cause cold sores or other symptoms.
Why It Might Be Ordered
Your healthcare provider may order this test if you have symptoms like cold sores, recurrent mouth ulcers, or if you’re at higher risk for HSV-1 (e.g., due to immune conditions or recent exposure). It can also be used to confirm a diagnosis when other tests are inconclusive.
How the Test Works
A small sample of your whole blood is collected and analyzed using a specialized probe-based nucleic acid amplification technique. This method detects even very small amounts of HSV-1 DNA, helping to identify active infection quickly.
What to Expect Before the Test
No special preparation is needed. You may have a simple blood draw, similar to other routine blood tests. If you’re on blood-thinning medications or have a history of bleeding disorders, let your provider know.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
HSV-1 is a common virus that usually causes mild infections, like cold sores. However, detecting HSV-1 DNA in blood can indicate active infection, especially if symptoms like fever, swollen lymph nodes, or painful sores are present. This test helps guide treatment decisions, such as antiviral medications, and can inform follow-up care for chronic or recurrent infections.
Short name
HSV-1 DNA Blood Test (NAA Probe)
Frequently asked questions
How long does it take to get results?
Can HSV-1 DNA be detected even if I don’t have symptoms?
What does a positive result mean?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy