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Herpes Simplex Virus Type 1 (HSV-1) DNA Quantitative PCR in Whole Blood

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of herpes simplex virus type 1 (HSV-1) genetic material in your blood using a highly sensitive DNA test. It helps determine if you have an active infection or if the virus is present at low levels that may indicate past or latent infection.

Quick summary

["This test helps assess whether HSV-1 is active in your body, which can guide treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
93439-8
Short code
HSV1 DNA Bld Ql NAA+n-prb
Synonyms
HSV1 DNA Bld Ql NAA+n-prb
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
non-probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms of herpes (such as sores, pain, or flu-like symptoms), if you have a history of HSV-1 infection, or if you are being evaluated for recurrent infections. It can also be used in research or specialized clinical settings to monitor viral load.

What to Expect Before the Test

No special preparation is needed. You’ll provide a small blood sample, usually drawn from your arm. The sample is processed to detect HSV-1 DNA without requiring fasting or avoiding certain medications.

What the Test Results Mean

Results are reported as the quantity of HSV-1 DNA in copies per milliliter of blood. A positive result means the virus is present, but it doesn’t always indicate an active outbreak. Low levels may suggest latent infection or chronic presence without symptoms.

How This Test Differs from Other HSV Tests

Unlike traditional HSV antibody tests (which detect immune response), this test directly measures viral DNA. It’s particularly useful for identifying active infections or viral load trends in research or specialized care.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-1 DNA Blood Test

Frequently asked questions

What does a positive result mean for my health?
A positive result indicates the presence of HSV-1 DNA, which may mean you have an active infection or latent virus. This doesn’t always mean you’ll have symptoms, but it can guide treatment decisions, especially if you’re managing frequent outbreaks or have specific health concerns.
Can this test detect latent HSV-1?
Yes, this test can detect low levels of HSV-1 DNA, which may indicate latent infection. However, it’s not definitive for diagnosing latent vs. active infection alone—results should be interpreted by your healthcare provider in context with symptoms and other tests.
How often should I get this test?
Your healthcare provider will determine the need for retesting based on your symptoms, medical history, or specific clinical reasons. Frequent testing may be recommended in research studies or for individuals with recurrent infections.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy