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Herpes Simplex Virus Type 1 DNA (Serum/Plasma) Quantitative Probe Test

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of genetic material from the herpes simplex virus type 1 (HSV-1) in your blood. It helps assess whether you have an active infection or if the virus is present in your system.

Quick summary

["This test can help diagnose or monitor herpes simplex virus type 1 infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
88128-4
Short code
HSV1 DNA Corn/Cnjt Ql NAA+probe
Synonyms
HSV1 DNA Corn/Cnjt Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms of an HSV-1 infection, such as sores or lesions, or if you have recurrent outbreaks. It may also be used to evaluate individuals with suspected primary infection or to monitor those with chronic infections, especially in immunocompromised patients.

What to Expect Before the Test

No special preparation is typically needed. You may have a blood sample drawn from a vein in your arm, similar to other blood tests. If you are taking blood-thinning medications or have a history of bleeding disorders, inform your healthcare provider beforehand.

What the Test Results Mean

Positive results indicate the presence of HSV-1 DNA in your blood, suggesting an active infection. The amount of virus detected can sometimes correlate with the severity of symptoms or disease activity. Results are qualitative (present or absent) based on the probe method used.

Common Reasons for Testing

This test is often used to confirm a diagnosis of HSV-1 infection when clinical symptoms are present, to determine the need for antiviral treatment, or to guide decisions about antiviral prophylaxis in high-risk individuals.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

HSV-1 DNA detection in blood can indicate active infection, which is crucial for initiating appropriate antiviral therapy. It can also help in assessing the effectiveness of treatment or managing chronic infections in individuals with weakened immune systems. However, it is important to note that HSV-1 is commonly found in saliva and other body fluids, so results should be interpreted in the context of clinical symptoms and other diagnostic findings.

Short name

HSV-1 DNA Test

Frequently asked questions

What does a positive result mean?
A positive result means that genetic material from HSV-1 was found in your blood sample. This suggests you are currently experiencing an active infection. It does not necessarily mean you will develop symptoms immediately, but it indicates the virus is present and may require medical evaluation.
How long does it take to get the results?
Test results are usually available within a few days to a week, depending on the laboratory’s processing time. Your healthcare provider will contact you with the results once they are ready.
Can HSV-1 DNA be detected in other body fluids besides blood?
Yes, HSV-1 DNA can be detected in various body fluids, including saliva, cerebrospinal fluid, and lesions. Blood testing is primarily used to assess systemic infection or monitor the virus in immunocompromised patients. The presence of HSV-1 DNA in different fluids can vary depending on the stage and location of the infection.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy