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Herpes Simplex Virus Type 1 (HSV-1) DNA in Saliva by Probe-Based Nucleic Acid Amplification Test

Published: August 9, 2026Updated: August 16, 2026

This test detects genetic material from the herpes simplex virus type 1 (HSV-1) in your saliva. It helps determine if you have an active infection or have been exposed to the virus.

Quick summary

["This test helps diagnose active herpes infections or assess exposure to HSV-1."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49987-1
Short code
HSV1 DNA # CSF NAA+probe
Synonyms
HSV1 DNA # CSF NAA+probe
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for the presence of HSV-1 DNA in your saliva using a specialized probe. This genetic material is unique to the virus and can indicate whether an infection is currently active or if you’ve been exposed recently.

How the Test Works

Saliva is collected and analyzed using a probe-based nucleic acid amplification technique. This method amplifies and detects tiny amounts of HSV-1 genetic material, allowing for highly sensitive detection.

Why It’s Done

Your healthcare provider may recommend this test if you have symptoms like cold sores, recurrent oral lesions, or if you’ve been exposed to HSV-1. It can also be used for screening in certain high-risk groups or research purposes.

What to Expect Before the Test

No special preparation is needed. You’ll simply provide a saliva sample, often by swabbing your inner cheek or spitting into a container. The sample is then sent to a lab for analysis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 Saliva Probe Test

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Your provider will discuss the findings with you during your follow-up visit.
Can I have false-positive or false-negative results?
While rare, false results can occur due to lab errors or sample contamination. If results are unclear, your provider may repeat the test or order additional tests for confirmation.
What does a positive result mean?
A positive result means HSV-1 DNA was detected in your saliva, suggesting active infection or recent exposure. This does not always mean you’ll develop symptoms, but it indicates the virus is present.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy