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Herpes Simplex Virus Type 1 (HSV-1) DNA in Serum/Plasma by Nucleic Acid Amplification Probe

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of genetic material from the herpes simplex virus type 1 (HSV-1) in your blood. It helps determine if you have an active infection.

Quick summary

["The test may help guide treatment decisions for HSV-1 infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
62470-0
Short code
HSV1 DNA # Mar NAA+probe
Synonyms
HSV1 DNA # Mar NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like sores, fever, or other signs of an HSV-1 infection, especially if they appear in unusual places (e.g., mouth, eyes). They might also order it if you have a history of HSV-1 and are experiencing recurrent outbreaks or if you’re at risk for complications.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. The sample is collected in a tube and sent to the lab for testing.

What the Test Results Mean

A positive result means genetic material from HSV-1 was found in your blood, indicating an active infection. A negative result suggests no active infection is detected at the time of testing. Results can vary based on the stage of infection.

How the Test Works

This test uses a specialized probe to detect the DNA of HSV-1. It amplifies a small amount of genetic material to make it detectable, even in very low concentrations. This method is highly sensitive and can help identify infections that might not be detected by other tests.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

HSV-1 DNA testing is particularly useful for diagnosing active infections, especially in cases where symptoms are unclear or when other tests are inconclusive. It can help confirm infections in immunocompromised individuals or those with unusual presentations. Early detection can guide treatment to reduce symptoms and complications.

Short name

HSV-1 DNA Test

Frequently asked questions

What does a positive result mean?
A positive result indicates that the genetic material of HSV-1 was found in your blood, suggesting an active infection. This could mean you have an ongoing herpes outbreak or latent infection that has recently reactivated. Your healthcare provider will discuss next steps, such as treatment options.
Can this test be used to diagnose a past HSV-1 infection?
No, this test specifically looks for active HSV-1 DNA in your blood. It cannot detect past infections or latent virus in nerve tissues. For history or past infections, other tests or medical history would be considered.
How soon after infection can I expect results?
Results can often be available within a few days to a week, depending on lab processing times. However, the timing of results may vary. Your healthcare provider will contact you once they have the results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy