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Herpes Simplex Virus Type 1 (HSV-1) Antibody, Serum (Qualitative Immunoassay)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the herpes simplex virus type 1 (HSV-1), which can indicate past infection with this virus. Antibodies are proteins the body produces in response to infection.

Quick summary

["This test helps determine if you’ve ever been exposed to HSV-1, a common virus that can cause cold sores or other infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109577-7
Short code
HSV1 DNA Msmt Bld
Synonyms
HSV1 DNA Msmt Bld
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like cold sores, recurrent mouth ulcers, or if you’ve been exposed to someone with HSV-1. It may also be used in certain research or screening contexts where past infection history is relevant.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample from a vein in your arm. The test is typically done in a lab setting and results are usually available within a few days.

What the Test Results Mean

A positive result means your body has produced antibodies against HSV-1, suggesting past infection. A negative result means no detectable antibodies were found, indicating either no prior infection or insufficient time since exposure for antibodies to develop.

Common Reasons for Testing

This test is often used to confirm past HSV-1 exposure rather than diagnose active infection. It’s not typically used to monitor current symptoms or treatment effectiveness.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 Antibody Test

Frequently asked questions

How long does it take to get the results of this test?
Results are usually available within 2 to 5 business days, depending on lab processing times. Your healthcare provider will contact you with the results once they are ready.
Can this test detect active herpes infection?
No, this test specifically looks for antibodies, which indicate past infection rather than active herpes symptoms. For diagnosing active infection, other tests or clinical evaluation may be needed.
Is there any risk or discomfort associated with this blood test?
There is a small risk of mild discomfort or bruising at the injection site. Most people experience minimal or no pain. A healthcare provider will explain the process and address any concerns before the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy