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Herpes Simplex Virus Type 1 DNA Detection by Nucleic Acid Amplification Test (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of genetic material from Herpes Simplex Virus Type 1 (HSV-1) in your blood, which may indicate an active infection.

Quick summary

["Assesses whether HSV-1 DNA is detected in your blood, useful for diagnosing active herpes infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50660-0
Short code
HSV1 DNA # SerPl NAA+probe
Synonyms
HSV1 DNA # SerPl NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects the genetic material (DNA) of HSV-1, a virus that can cause cold sores and other infections. This is done using a specialized lab technique that amplifies small amounts of viral DNA for analysis.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like sores around your mouth, fever, or other signs of an active HSV-1 infection, especially if you’ve had recent exposure or a history of herpes.

Sample Collection and Process

A blood sample is drawn from your arm, and the serum or plasma is sent to the lab. The lab uses a probe-based nucleic acid amplification method to identify HSV-1 DNA fragments, which are then analyzed for presence.

What the Results Mean

A positive result means HSV-1 DNA was found, suggesting an active infection. A negative result means no detectable viral DNA was found in this sample, but it doesn’t rule out past infection or latent virus presence.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-1 DNA (Serum/Plasma)

Frequently asked questions

Can HSV-1 DNA be detected even if I don’t have symptoms?
Yes, HSV-1 DNA can be detected in blood even when you don’t have visible symptoms, especially during the early or active phases of infection. This is why testing is important for diagnosing active herpes, even if symptoms are subtle or absent.
What does a positive result mean for my treatment?
A positive result indicates an active HSV-1 infection and may guide treatment with antiviral medications to manage symptoms, reduce virus spread, and shorten the duration of outbreaks.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Your healthcare provider will discuss the results with you during your follow-up visit.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy