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Herpes Simplex Virus Type 1 Immunoglobulin G Antibody (IgG) - Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures your body’s immune response to herpes simplex virus type 1 (HSV-1), a common virus that can cause cold sores and other infections.

Quick summary

["It helps determine if you’ve been exposed to HSV-1 and whether your immune system has produced antibodies against it."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
28001-6
Short code
HSV1 IgG CSF Ql IB
Synonyms
HSV1 IgG CSF Ql IB
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms of HSV-1 infection (such as sores or lesions), if you’ve had recent exposure to someone with HSV-1, or if you’re investigating unexplained recurrent cold sores. It can also be used in certain research or screening contexts.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, typically drawn from a vein in your arm. The sample is sent to a lab for testing.

What the Test Results Mean

Positive results indicate the presence of HSV-1-specific IgG antibodies, suggesting past exposure and immunity. Negative results mean no detectable antibodies, which may indicate no prior exposure or an acute infection (though other tests may be needed).

Possible Results and Next Steps

If you have symptoms of an active HSV-1 infection, your provider may recommend additional testing (such as HSV culture or PCR) to confirm the current infection status. If you’re asymptomatic but have a positive result, it confirms past exposure.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 IgG Antibody

Frequently asked questions

How often should I get this test?
This test is generally not repeated routinely unless you have specific symptoms, recent exposure, or a clinical need to monitor immunity. If you’re unsure, discuss with your healthcare provider.
Can I get HSV-1 from this test?
No, this test does not transmit HSV-1. Blood samples are handled in a sterile manner to prevent infection.
What does a high or low antibody level mean?
A high antibody level suggests past infection and immunity, while a low or absent level may indicate no prior exposure or an acute infection. Results should be interpreted by a healthcare professional in the context of your medical history.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy