Skip to content

Herpes Simplex Virus Type 1 Immunoglobulin G Antibody (IgG) by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against the herpes simplex virus type 1 (HSV-1) in your blood. Antibodies are your body’s natural defense against infections.

Quick summary

["This test helps determine if you’ve been exposed to HSV-1, which can cause cold sores or other infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22333-9
Short code
HSV1 IgG Titr CSF
Synonyms
HSV1 IgG Titr CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82977
SNOMED
3110003
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects **IgG antibodies** specific to HSV-1, indicating whether your immune system has encountered this virus in the past. IgG antibodies are typically present for long-term immunity after an infection has resolved.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like cold sores, recurrent oral or genital sores, or if you’re at risk for HSV-1 exposure (e.g., due to sexual history, immune conditions, or newborn care). It can also help diagnose or monitor conditions linked to HSV-1.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The blood is processed to separate serum (liquid part of blood without clots) for testing. This test does not require fasting.

What to Expect Before the Test

No special preparation is needed. You may have some mild discomfort or bruising at the injection site, but this usually fades quickly. If you’re on blood-thinning medication, let your provider know before the test.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: csf

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 IgG Antibody

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your healthcare provider will discuss the meaning of your results with you.
Can I have false-positive or false-negative results?
Rarely, test results may vary due to recent infections, immune conditions, or cross-reactions with other viruses. If your results are unclear, your provider may recommend retesting or additional testing.
Does this test detect active herpes outbreaks?
No, this test only measures antibodies for past exposure. For diagnosing active herpes (e.g., cold sores), your provider may use clinical symptoms or other tests like viral culture or PCR.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy