Herpes Simplex Virus Type 1 Immunoglobulin M Antibody (Serum/Plasma)
This test measures the presence of Immunoglobulin M (IgM) antibodies against Herpes Simplex Virus Type 1 (HSV-1). IgM antibodies are typically produced shortly after infection and can help identify recent HSV-1 exposure.
["IgM antibodies to HSV-1 may indicate a recent infection, but they can also be present in some people without active infection."]
Key facts at a glance
- LOINC
- 13251-4
- Short code
- HSV1 IgM CSF-aCnc
- Synonyms
- HSV1 IgM CSF-aCnc
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
Herpes Simplex Virus Type 1 (HSV-1) is a common virus that can cause cold sores (fever blisters) around the mouth and lips. IgM antibodies are part of your immune system’s response to infection. This test detects IgM antibodies specific to HSV-1, which can appear within days to weeks after exposure. While IgM is useful for identifying recent infection, it may not be present long-term and can sometimes be found in people who have never been infected.
Why It Might Be Ordered
Your healthcare provider may order this test if you have symptoms like cold sores, sores around the mouth, or other signs of HSV-1 infection. It may also be used in certain situations where recent exposure to HSV-1 is suspected, such as after contact with someone who has an active infection.
What to Expect Before the Test
No special preparation is needed for this test. You will likely have a small needle inserted into your arm or hand to draw blood. The process is quick and usually causes only minor discomfort. If you are pregnant, breastfeeding, or have a bleeding disorder, let your healthcare provider know before the test.
What to Expect After the Test
After the blood is drawn, you may feel a small bruise or slight pain at the site. Apply gentle pressure to stop any bleeding. Avoid vigorous activity for a few hours. If you experience excessive bleeding, swelling, or signs of infection (like increased pain or redness), contact your healthcare provider.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
IgM antibodies to HSV-1 can indicate a recent infection, but they are not definitive proof of active disease. These antibodies typically decline over time and may not be detected in people who have had long-term infection. While HSV-1 is usually mild and manageable, it can cause severe complications in rare cases, especially in newborns or immunocompromised individuals. If you test positive, your healthcare provider may recommend further testing or monitoring to assess your health status.
Short name
HSV-1 IgM Antibody
Frequently asked questions
Can IgM antibodies to HSV-1 stay in my system long-term?
What does a positive result mean?
Can HSV-1 be treated if detected by this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy