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Herpes Simplex Virus 2 Antibody, Total (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against the herpes simplex virus type 2 (HSV-2), which causes genital herpes. Antibodies indicate your immune system has encountered the virus before.

Quick summary

["Checks for past or current exposure to genital herpes virus type 2."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27087-6
Short code
HSV2 Ab CSF-aCnc
Synonyms
HSV2 Ab CSF-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like sores, pain, or unusual discharge in the genital area, or if you have a history of genital herpes. It can also be used to confirm a diagnosis when symptoms are unclear or if you’re at risk due to sexual history.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. If you’re pregnant or breastfeeding, let your provider know before testing.

What the Results Mean

Positive results mean you likely have had HSV-2 before, though you may not have symptoms. Negative results suggest you haven’t been exposed to the virus at the time of testing. Results don’t indicate active infection status.

Possible Results and Next Steps

If positive, discuss treatment options with your provider, such as antiviral medications to manage symptoms or reduce transmission. If negative but you suspect exposure, retest in a few months or discuss other diagnostic methods.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-2 Antibody Test

Frequently asked questions

How does this test help with diagnosis or treatment?
This test helps confirm a past infection with HSV-2, which is crucial for managing chronic conditions, preventing complications, and guiding treatment decisions. It also supports risk assessment for sexual partners and helps monitor recurrence patterns.
Can this test detect active herpes outbreaks?
No, this test only detects antibodies, indicating past exposure—not active infection. For diagnosing an active outbreak, your provider may recommend viral culture or PCR testing.
What if I have a weak immune system?
If you have a weakened immune system, this test can help assess your risk for severe complications from HSV-2. Your provider may recommend additional monitoring or preventive strategies based on your results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy