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Herpes Simplex Virus 2 Antibody, Total (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the herpes simplex virus type 2 (HSV-2), which can indicate past or current infection with this sexually transmitted virus.

Quick summary

["This test helps determine if you’ve been exposed to HSV-2, which can cause genital herpes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44492-7
Short code
HSV2 Ab CSF Ql IF
Synonyms
HSV2 Ab CSF Ql IF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like sores, itching, or unusual discharge in the genital area, or if you’ve had multiple sexual partners. It can also be used to confirm a diagnosis of genital herpes or assess exposure in certain high-risk situations.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. If you’re tested for HSV-2 antibodies, it’s best to wait at least 2 weeks after any symptoms or recent exposure to ensure accurate results.

What the Test Results Mean

A positive result means you have antibodies to HSV-2, suggesting past infection. A negative result means you likely do not have current HSV-2 infection, but it doesn’t rule out past exposure. Results may take several days to return.

Common Missteps to Avoid

Avoid testing too soon after exposure or symptoms—waiting improves accuracy. If you have active genital sores, inform your provider before testing to avoid false results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-2 Antibody Test

Frequently asked questions

How long does it take to get results?
Test results typically take 2 to 7 business days to be available. Some labs may provide preliminary results sooner, but final confirmation may take longer.
Can I have false-positive or false-negative results?
Yes, both false positives and false negatives can occur. False positives may happen if you have other infections or recent vaccinations. False negatives can occur if tested too early after exposure. Your provider will discuss results in detail and may recommend retesting if needed.
Does this test detect active herpes outbreaks?
No, this test detects antibodies, which indicate past infection, not active outbreaks. If you suspect an active infection, your provider may recommend additional testing, such as viral culture or PCR, to confirm current herpes activity.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy