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Herpes Simplex Virus 2 Antibody, Fluid (IgG)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies to the herpes simplex virus type 2 (HSV-2) in your blood or body fluids. These antibodies indicate past or current infection with HSV-2, which causes genital herpes.

Quick summary

["This test helps determine if you’ve been exposed to HSV-2 and may support diagnosis or monitoring of infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44491-9
Short code
HSV2 Ab Fld Ql
Synonyms
HSV2 Ab Fld Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like sores, pain, or unusual discharge in the genital area, or if you have a history of genital herpes. It can also be used to confirm a diagnosis when symptoms are unclear or to check for past exposure in certain clinical situations.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw from a vein in your arm or a fluid sample (like saliva or urine) collected for testing, depending on the lab’s protocol. Always follow your provider’s instructions.

What the Test Results Mean

Positive results indicate the presence of HSV-2 antibodies, suggesting past infection. Negative results mean no detectable antibodies, but this doesn’t always rule out current infection without symptoms. Always discuss results with your healthcare provider.

Common Misconceptions

This test does not diagnose active herpes outbreaks. It only shows if you’ve had HSV-2 before. If you have symptoms, your provider may recommend additional testing or evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-2 IgG Antibody (Serum/Plasma)

Frequently asked questions

What does it measure?
This test measures IgG antibodies to HSV-2, which are produced by your immune system in response to past infection. These antibodies can persist long-term and help confirm exposure.
Can it detect current infection?
No, this test alone cannot detect active herpes sores or current infection. It is typically used alongside clinical evaluation or other tests (like PCR) for diagnosis.
How does it differ from HSV-1 testing?
HSV-2 antibodies are specific to genital herpes caused by HSV-2, while HSV-1 antibodies relate to oral herpes. This test focuses only on HSV-2, so it won’t detect HSV-1 infections.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy