Herpes Simplex Virus Type 2 Antibody Measurement by Serology (Cerebrospinal Fluid)
This test checks for antibodies to herpes simplex virus type 2 (HSV-2) in your cerebrospinal fluid (CSF). Antibodies indicate your immune system has encountered the virus, which may suggest past infection or exposure.
["This test helps diagnose or evaluate suspected HSV-2 infection in the central nervous system."]
Key facts at a glance
- LOINC
- 110918-0
- Short code
- HSV2 Ab Msmt CSF
- Synonyms
- HSV2 Ab Msmt CSF
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like severe headaches, neck stiffness, confusion, or neurological issues that could be linked to a viral infection in the brain or spinal cord. It’s also used in cases of suspected meningitis or encephalitis caused by HSV-2, especially in individuals with weakened immune systems or recurrent infections.
What to Expect During the Test
A small amount of cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then analyzed in a lab to detect HSV-2 antibodies. This process is generally safe but may cause mild discomfort during the procedure.
What the Results Mean
Positive results indicate the presence of HSV-2 antibodies in your CSF, suggesting past infection or active infection in the nervous system. Negative results mean no detectable antibodies were found. Interpretation depends on clinical context, including symptoms, medical history, and other test results.
Preparation for the Test
No special preparation is needed. You may be asked to fast or avoid certain medications, but this depends on your healthcare provider’s instructions. Hydration is often encouraged before the procedure.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
HSV-2 antibodies in CSF are critical for diagnosing herpes encephalitis or meningitis caused by HSV-2. While HSV-1 is more commonly associated with cold sores, HSV-2 can cause severe neurological infections. Early detection and treatment with antiviral medications can improve outcomes and reduce complications.
Short name
HSV-2 Antibody in CSF
Frequently asked questions
How long does it take to get the results of this test?
Can I drink alcohol before this test?
What are the risks or side effects of this procedure?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy