Herpes Simplex Virus 2 Antibody, Total (Serum/Plasma)

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of genital herpes (e.g., sores, itching, or discharge), a history of genital herpes, or if you’re at higher risk for infection (e.g., sexually active with multiple partners). It can also be used during pregnancy to assess risk to your baby.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. It usually takes a few minutes. Avoid alcohol for 24 hours before the test if possible.

What the Test Results Mean

Positive results mean you likely have antibodies to HSV-2, suggesting past or current infection. Negative results mean you do not have detectable antibodies at this time. Results alone don’t confirm active infection; symptoms or clinical evaluation may be needed.

Common Reasons for Testing

This test is often used to diagnose HSV-2 infection, monitor treatment effectiveness, or assess risk in sexual health evaluations. It’s not a quick test for active herpes sores—those are usually diagnosed with swab tests.