Skip to content

Herpes Simplex Virus 2 Antibody, Serologic Test (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This blood test checks for antibodies to the herpes simplex virus type 2 (HSV-2), which can indicate past or current infection with genital herpes caused by this virus.

Quick summary

["This test helps determine if you’ve been exposed to HSV-2 and may affect treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13323-1
Short code
HSV2 Ab Ser IF-aCnc
Synonyms
HSV2 Ab Ser IF-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like sores, pain in the genital area, or if you’ve had multiple sexual partners. It’s also used for screening during pregnancy or before certain medical procedures.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. It usually takes a few minutes, and you can resume normal activities afterward.

What the Test Results Mean

A positive result means your blood contains antibodies to HSV-2, suggesting past infection. A negative result means no detectable antibodies were found at this time. Results don’t confirm active infection—additional testing may be needed if symptoms persist.

How the Test Works

The test uses a blood sample to detect specific antibodies produced by your immune system in response to HSV-2. This is done through an immunoassay method to identify the presence of these antibodies.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test helps diagnose past HSV-2 infection, which is important for managing sexually transmitted infections (STIs). It can guide treatment decisions, especially in pregnancy or for individuals with recurrent symptoms. Early detection can help prevent complications and inform preventive measures.

Short name

HSV-2 Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result indicates you likely had HSV-2 at some point in the past, but it doesn’t confirm whether you currently have an active infection. You may still be at risk for outbreaks.
Can I still get tested if I have active herpes sores?
Yes, but your healthcare provider may recommend additional testing (like a viral culture) to check for active infection. This test alone can’t distinguish between past and current infection.
How often should I get retested?
There’s no standard retesting schedule unless you have symptoms or specific clinical reasons. If you’re pregnant or have recurrent symptoms, your provider may recommend follow-up testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy