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Herpes Simplex Virus Type 2 Antibody, Total (IgG + IgM) by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the total antibodies against herpes simplex virus type 2 (HSV-2), which causes genital herpes. It helps determine if you’ve ever been exposed to the virus or if you currently have an active infection.

Quick summary

["This test helps diagnose past or current herpes infections by detecting antibodies in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43029-8
Short code
HSV2 Ab Titr CSF
Synonyms
HSV2 Ab Titr CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like sores, pain, or unusual discharge in the genital area, or if you have a history of genital herpes. It can also be used to confirm a diagnosis in people with recurrent outbreaks or those who suspect exposure.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. It usually takes a few minutes, and you may feel a brief pinch. If you’re pregnant or breastfeeding, let your provider know before the test.

What the Test Results Mean

Positive results indicate you’ve been exposed to HSV-2 and developed antibodies. The presence of IgG antibodies suggests past infection, while IgM antibodies may indicate a recent infection. If you have symptoms, a positive result strongly suggests genital herpes.

Possible Side Effects or Risks

The most common side effect is a small bruise or mild soreness at the injection site. Rarely, you might experience a reaction to the blood draw, such as dizziness or fainting. If you experience severe pain, swelling, or signs of infection at the site, contact your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-2 Antibody Total

Frequently asked questions

What does a positive result mean for my health?
A positive result means you have antibodies against HSV-2, which means you’ve been infected at some point. This doesn’t necessarily mean you’re currently active or contagious, but it confirms past exposure. If you have symptoms, it confirms genital herpes, and you should discuss treatment options with your healthcare provider.
Can this test detect active herpes outbreaks?
No, this test only detects antibodies, not active virus. For diagnosing an active infection, your provider may recommend a viral culture or PCR test.
How often should I get this test?
If you have genital herpes, your provider may recommend retesting if symptoms recur or if you suspect reinfection. If you’re asymptomatic, this test may not be necessary unless you’re planning pregnancy or have risk factors for reinfection.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy