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Herpes Simplex Virus Type 2 Antibody Titration (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies against herpes simplex virus type 2 (HSV-2), which causes genital herpes. Antibodies indicate past or current infection.

Quick summary

["This test helps determine if you’ve been exposed to genital herpes virus."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43028-0
Short code
HSV2 Ab Titr Ser
Synonyms
HSV2 Ab Titr Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects antibodies produced by your immune system in response to HSV-2. These antibodies are created when your body fights off the virus. The antibody level helps determine whether you’ve had an infection before or if you’re currently infected.

Why Might You Need This Test?

Your healthcare provider may recommend this test if you have symptoms like sores, itching, or unusual discharge in the genital area, or if you have recurrent outbreaks. It may also be used during pregnancy to check for HSV-2 infection.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The sample is sent to a lab where it is tested for HSV-2 antibodies using an immunoassay method. The result is reported as a quantitative antibody titer, indicating the strength of your immune response.

What Are the Possible Results?

Results may show either a negative (no detectable antibodies) or positive (detectable antibodies) for HSV-2. A positive result suggests past or current infection, but it does not confirm active symptoms at the time of testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-2 Antibody Test

Frequently asked questions

What Does a Positive Result Mean?
A positive result means your body has detected HSV-2 antibodies, indicating past infection. This does not necessarily mean you have active symptoms now, but it confirms exposure. You may still need further evaluation if you have symptoms or concerns about transmission.
Can I Get Treated If My Test Is Positive?
Yes, if you test positive, your healthcare provider may recommend antiviral medications to manage symptoms, reduce outbreaks, and prevent transmission. Treatment is especially important during pregnancy.
How Often Should I Get This Test?
The frequency depends on your medical history, symptoms, and risk factors. If you have recurrent outbreaks or are pregnant, your provider may recommend retesting or monitoring. Otherwise, it’s typically done as needed for specific concerns.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy