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Herpes Simplex Virus 2 Antibody, Genital Site (Qualitative Immunoassay)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the herpes simplex virus type 2 (HSV-2), which causes genital herpes. It helps determine if you’ve been exposed to the virus or if you have an active infection.

Quick summary

["This test helps diagnose or rule out genital herpes caused by HSV-2."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31849-3
Short code
HSV2 Ag Genital Ql
Synonyms
HSV2 Ag Genital Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like sores, itching, or pain in the genital area, unexplained genital sores, or if you’ve had multiple sexual partners. It can also be used during pregnancy to check for HSV-2 infection.

What to Expect Before the Test

No special preparation is needed. The test is typically done on a blood sample drawn from a vein in your arm. If you’re pregnant, your provider may also collect a sample from your genital area.

What the Test Results Mean

Positive results indicate you have antibodies to HSV-2, meaning you’ve likely been exposed to the virus at some point. Negative results suggest you do not have detectable antibodies, but this doesn’t rule out past exposure. Active herpes sores would require additional testing.

Common Causes of Positive Results

A positive result can occur if you’ve had HSV-2 infection in the past, even if you don’t currently have symptoms. It may also appear if you’re actively infected with the virus, though symptoms can vary widely.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-2 Antibody (Genital)

Frequently asked questions

What does a positive result mean for my health?
A positive result means you have antibodies to HSV-2, which means you’ve been exposed to the virus. This doesn’t necessarily mean you’re currently infected, but it does indicate past exposure. If you have symptoms like sores or discomfort, consult your provider for further evaluation, as active infection may require treatment.
Can I still have sex if my test is positive?
If you have symptoms of genital herpes (such as sores, blisters, or itching), avoid sexual contact until the sores heal completely. Even if you’re asymptomatic, HSV-2 can still be transmitted. Always use protection and discuss your results with your partner.
How often should I get this test?
There’s no routine recommendation for this test unless you have symptoms, a history of genital herpes, or are at higher risk for infection. If you’re pregnant, your provider may recommend testing during pregnancy to monitor for HSV-2.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy