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Herpes Simplex Virus Type 2 Antibody, Serum (Qualitative PCR)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to herpes simplex virus type 2 (HSV-2), which can help identify past or current infection with genital herpes caused by HSV-2.

Quick summary

["This test helps determine if you’ve been exposed to HSV-2, which can cause genital herpes symptoms or asymptomatic infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31851-9
Short code
HSV2 Ag Spec Ql
Synonyms
HSV2 Ag Spec Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test uses a Polymerase Chain Reaction (PCR) method on serum to detect genetic material from HSV-2. Antibodies (immune proteins) produced by your body in response to infection are identified, confirming exposure to the virus.

Why It’s Done

Doctors may order this test if you have symptoms like sores, itching, or pain in the genital area, or if you have a history of genital herpes. It can also be used for screening in high-risk groups or during pregnancy to assess transmission risk.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in your arm. The serum portion is separated and sent to the lab for PCR analysis to detect HSV-2 genetic material.

What to Expect Before the Test

No special preparation is needed. You may have some mild discomfort from the needle, but it usually resolves quickly. Avoid alcohol or certain medications for 24 hours before testing if instructed by your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results indicate past or current HSV-2 infection. While antibodies suggest exposure, they don’t always correlate with active symptoms. This test helps guide treatment decisions, manage outbreaks, and assess risk for transmission, especially important during pregnancy.

Short name

HSV-2 Antibody Screen (Serum)

Frequently asked questions

What Does a Positive Result Mean?
A positive result means your body has detected HSV-2 genetic material or antibodies, confirming past or possible current infection. This doesn’t mean you’re currently experiencing symptoms, but it’s important to discuss with your healthcare provider for further evaluation.
What If I Have Symptoms?
If you have genital sores, pain, or other symptoms, your provider may recommend additional testing (like viral culture) to confirm active infection. Antibody tests alone can’t distinguish between past infection and current symptoms.
Can This Test Be Used for Pregnant Women?
Yes, this test is commonly used during pregnancy to screen for HSV-2, as it helps identify transmission risk to the baby. If positive, your provider will discuss treatment options and monitoring plans.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy