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Herpes Simplex Virus Type 2 Antibody, IgG (Serum or Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against the herpes simplex virus type 2 (HSV-2), which causes genital herpes. Antibodies indicate past or current infection.

Quick summary

["This test helps determine if you’ve been exposed to HSV-2, which can affect skin, mucous membranes, or the nervous system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44502-3
Short code
HSV2 Ag Tiss Ql
Synonyms
HSV2 Ag Tiss Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms of genital herpes, such as sores or itching in the genital or anal area, or if you have recurrent outbreaks. It can also be used to screen for HSV-2 in individuals at higher risk, such as those with multiple sexual partners or a history of sexually transmitted infections (STIs).

What to Expect During the Test

A blood sample is taken from a vein in your arm. You may feel a small pinch when the needle is inserted, but the procedure usually takes less than five minutes. The blood is then sent to a lab for testing.

What the Results Mean

If your test is positive for HSV-2 antibodies, it means your body has detected and fought off the virus at some point. This does not necessarily mean you currently have an active infection, but it confirms past exposure. A negative result means you likely have not been infected with HSV-2 in the past.

Preparation and Care

No special preparation is needed for this blood test. You can eat, drink, or take medications as usual on the day of your test. If you are pregnant, let your healthcare provider know before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

IgG HSV-2 Antibody

Frequently asked questions

What does a positive result mean?
A positive result indicates that your body has produced antibodies against HSV-2, meaning you have been exposed to the virus at some point. This does not necessarily mean you have an active infection right now, but it confirms past exposure. If you have symptoms like sores or itching, you may need further testing to determine if the infection is active.
Can this test detect an active infection?
While this test detects antibodies from past exposure, it does not directly measure an active infection. If you suspect you have an active HSV-2 infection, your healthcare provider may recommend additional tests, such as viral culture or PCR (Polymerase Chain Reaction) testing, to confirm the presence of the virus.
How long does it take to get results?
Results for this test are typically available within a few days to a week, depending on the lab’s processing time. Your healthcare provider will contact you with the results once they are ready.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy