Herpes Simplex Virus 2 Antibody, Qualitative (IgG)
This test detects antibodies to the herpes simplex virus type 2 (HSV-2), which causes genital herpes. It helps determine if you’ve been exposed to the virus and whether your immune system has mounted a response.
["This test checks for past or current exposure to genital herpes virus."]
Key facts at a glance
- LOINC
- 44497-6
- Short code
- HSV2 Ag Vag Ql
- Synonyms
- HSV2 Ag Vag Ql
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test looks for IgG antibodies specific to HSV-2 in your blood. IgG antibodies are produced by your immune system in response to past infection. They remain in your system for a long time after the initial infection has cleared, providing long-term immunity.
Why It’s Done
Your healthcare provider may recommend this test if you have symptoms of genital herpes (e.g., sores, itching, or pain in the genital area), a history of genital herpes, or if you’re sexually active with partners who have the virus. It can also be used during pregnancy to assess risk of transmission to the baby.
How It Works
A blood sample is taken from a vein in your arm. The sample is then analyzed using an immunoassay method to detect the presence of HSV-2-specific IgG antibodies.
What to Expect Before the Test
No special preparation is needed. You may want to avoid alcohol for 24 hours before the test, as it can sometimes affect lab results.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Positive results indicate past exposure to HSV-2, meaning you’ve likely had the virus at some point. While this doesn’t confirm an active infection, it helps rule out other causes of genital symptoms. Negative results mean the test did not detect HSV-2 antibodies, suggesting you may not have been previously exposed or the test may not have been performed at the right time. This test is not used to diagnose an active outbreak but can guide further evaluation if needed.
Short name
HSV-2 Antibody Test (IgG)
Frequently asked questions
What does a positive result mean?
Can this test detect an active infection?
How long after exposure might I get accurate results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy