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Herpes Simplex Virus Type 2 DNA Quantitative Nucleic Acid Amplification Test (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of genetic material from the herpes simplex virus type 2 (HSV-2) in your blood. It helps confirm an infection that may not yet cause symptoms.

Quick summary

["A key step in diagnosing herpes infections when symptoms aren’t obvious."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
92873-9
Short code
HSV2 DNA Bld Ql NAA+probe
Synonyms
HSV2 DNA Bld Ql NAA+probe
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like sores, pain, or unusual rashes that could be caused by HSV-2, especially if you’ve had multiple sexual partners or have a history of sexually transmitted infections. It’s also used to diagnose infections in people with no visible symptoms or to confirm a diagnosis in cases where other tests are inconclusive.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. If you’re concerned about discomfort, let your provider know so they can take steps to minimize it.

What the Test Results Mean

Positive results indicate the presence of HSV-2 DNA, suggesting an active infection. Negative results mean the virus isn’t detected in the sample at this time. Results don’t show how long you’ve had the infection or its severity.

Common Causes of False Results

Occasionally, test results may be affected by factors like recent blood transfusions, certain medications, or laboratory errors. If you have concerns, discuss your results with your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-2 DNA Test (Serum/Plasma)

Frequently asked questions

How often should I get this test?
If you have an active HSV-2 infection, your provider may recommend retesting periodically to monitor the virus or check for treatment response. If you’re asymptomatic, testing may be done only if you’re at higher risk (e.g., during pregnancy, before surgery, or if you’re sexually active with multiple partners).
What does a positive result mean for my health?
A positive result means you have HSV-2 DNA in your blood, confirming an infection. While this doesn’t determine your risk for complications, it helps guide treatment decisions. HSV-2 can be managed with antiviral medications to reduce symptoms and outbreaks.
Can this test be used to diagnose HSV-2 in other body fluids?
No, this test specifically looks for HSV-2 DNA in blood (serum/plasma). For other fluids like saliva or vaginal swabs, a different test or specimen type would be used.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy