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Herpes Simplex Virus 2 (HSV-2) DNA Detection by Nucleic Acid Amplification Probe

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of genetic material from the herpes simplex virus type 2 (HSV-2) in your body fluids. It helps determine if you have been infected with HSV-2, which can cause genital herpes.

Quick summary

["This test helps diagnose genital herpes caused by HSV-2 and guides treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49990-5
Short code
HSV2 DNA # CSF NAA+probe
Synonyms
HSV2 DNA # CSF NAA+probe
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like sores, itching, or unusual discharge in the genital area, or if you have a history of genital herpes. It may also be used to confirm a diagnosis in cases where symptoms are unclear or if you have recurrent outbreaks.

How the Test Works

The test involves collecting a sample of fluid (such as saliva or vaginal/penile secretions) and analyzing it for HSV-2 DNA using a sensitive molecular method. This method detects the virus’s genetic material even when symptoms are not present.

Sample Collection

A healthcare provider will collect a sample, often from the affected area or a swab of fluid. The sample is then sent to a lab for testing. You may be asked to avoid sexual contact or certain hygiene practices before the test to ensure accurate results.

What to Expect During Testing

The test is usually quick and painless. You may experience mild discomfort or irritation at the sample collection site, but it typically resolves shortly after. Results are usually available within a few days.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-2 DNA Test

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 2 to 5 business days, depending on the lab processing time. Your healthcare provider will contact you once the results are ready.
Can I have false-positive or false-negative results?
While rare, false results can occur due to lab errors or sample handling issues. False negatives may happen if the sample is collected too early or too late in an outbreak. If your test is negative but you suspect HSV-2 infection, your provider may recommend retesting or additional testing methods.
Is this test safe for pregnant women?
Yes, this test is safe for pregnant women. It helps determine if the virus is present, which is important for managing risks to the baby during pregnancy. If you are pregnant and have symptoms, discuss testing with your healthcare provider.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy