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Herpes Simplex Virus Type 2 DNA Detection by Nucleic Acid Amplification Probe

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of genetic material from herpes simplex virus type 2 (HSV-2), which causes genital herpes. It helps confirm infection after symptoms appear or identify it in asymptomatic individuals.

Quick summary

["This test helps diagnose genital herpes caused by HSV-2, even when symptoms are mild or absent."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
60462-9
Short code
HSV2 DNA # Spec NAA+probe
Synonyms
HSV2 DNA # Spec NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

When Is This Test Used?

Your healthcare provider may recommend this test if you have symptoms like sores, blisters, or itching in the genital area, or if you have recurring outbreaks. It may also be used for routine screening in high-risk individuals or during pregnancy to assess risk of transmission to a baby.

How Is the Test Performed?

A small sample of fluid from a sore or lesion is collected during an active outbreak. If symptoms aren’t present, a blood sample may be taken instead. The sample is analyzed in a lab using a specialized technique that detects the virus’s genetic material.

What Does a Positive Result Mean?

A positive result means the virus’s DNA is present in your sample, confirming HSV-2 infection. This doesn’t indicate how severe your infection is or how long you’ve been infected, but it confirms active or past exposure.

What Does a Negative Result Mean?

A negative result means the virus’s genetic material wasn’t detected in the sample at that time. However, HSV-2 can be present without symptoms, so testing again later may be needed if you suspect infection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-2 DNA Test

Frequently asked questions

Why might I need this test even if I don’t have symptoms?
If you have a history of genital herpes, a partner with the virus, or are pregnant, your doctor may recommend testing to confirm infection, even without visible symptoms. This helps prevent complications and ensures proper care.
How soon after exposure can I get tested?
Testing is most accurate when done during an active outbreak (sores/blisters). If symptoms aren’t present, testing may still be possible with a blood sample, but results may not be as definitive. Follow your provider’s guidance.
Can this test be used to determine how long I’ve had herpes?
No, this test only confirms the presence of HSV-2 DNA at the time of testing. It doesn’t provide information about the duration of infection, but it helps confirm active or past exposure.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy