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Herpes Simplex Virus Type 2 DNA Quantitative Polymerase Chain Reaction (PCR) in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of genetic material from the herpes simplex virus type 2 (HSV-2) in your blood. It helps determine if you have an active infection or have been exposed recently.

Quick summary

["This test helps confirm or monitor herpes simplex virus type 2 infection in your bloodstream."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16131-5
Short code
HSV2 DNA Spec Ql NAA+probe
Synonyms
HSV2 DNA Spec Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like sores, pain, or unusual discharge, especially if you suspect genital herpes caused by HSV-2. It can also be used to check for recent exposure or to confirm an infection in people with no obvious symptoms. Sometimes, it’s part of ongoing monitoring for those with recurrent herpes outbreaks.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. If you’re taking blood thinners, let your provider know to avoid unnecessary bleeding.

What the Test Results Mean

A positive result means genetic material from HSV-2 was found in your blood, indicating an active infection. A negative result means no detectable genetic material was found at the time of testing. Results can vary based on the stage of infection and may not always match symptoms.

Common Questions About This Test

This test focuses on detecting HSV-2 DNA, not antibodies. Antibody tests can show past exposure or immunity, while this test identifies current infection status.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-2 DNA PCR (Serum/Plasma)

Frequently asked questions

Will I need to take any medications if my test is positive?
If your test is positive, your healthcare provider may recommend antiviral medications to manage symptoms, reduce outbreaks, and prevent complications. Treatment can also help lower the risk of spreading the virus to others.
Can I still have sex if my test is positive?
Yes, but it’s important to use barrier methods like condoms to prevent spreading HSV-2 to sexual partners. Avoiding sex during outbreaks or when symptoms are present is also recommended.
How often should I get this test?
The frequency depends on your medical history and symptoms. Your provider may recommend retesting if symptoms recur, if you suspect recent exposure, or as part of routine monitoring for chronic infections.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy