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Herpes Simplex Virus 2 DNA Detection by Nucleic Acid Amplification (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of genetic material from the herpes simplex virus type 2 (HSV-2) in your blood. It helps determine if you have been infected with HSV-2, which can cause genital herpes.

Quick summary

["This test helps diagnose genital herpes caused by HSV-2 and supports treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
62475-9
Short code
HSV2 DNA # Tiss NAA+probe
Synonyms
HSV2 DNA # Tiss NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like sores, pain, or unusual discharge in the genital area, or if you have a history of genital herpes. It can also be used to confirm a diagnosis when symptoms are unclear or to check for recurrence of infection.

How the Test Works

A small blood sample is taken from a vein in your arm. The sample is then tested using a specialized technique that detects the virus’s genetic material (DNA) in your blood. This method is highly sensitive and can identify even small amounts of the virus.

Sample Collection and Preparation

The blood sample is collected in a special tube and sent to a lab where it is processed to isolate the DNA. The test uses a probe designed to specifically bind to HSV-2 DNA, allowing for accurate detection.

What to Expect Before the Test

No special preparation is needed before this test. However, if you are taking certain medications that affect blood clotting, let your provider know. Avoid alcohol before the test if it may affect your blood work.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-2 DNA Test

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 24 to 72 hours, depending on the lab’s processing schedule. Your healthcare provider will contact you with the results once they are ready.
What does a positive result mean?
A positive result indicates that the genetic material of HSV-2 was found in your blood, suggesting you have an active or past infection with the virus. This does not necessarily mean you are currently experiencing symptoms, but it confirms the presence of the virus in your system.
Can this test be used to determine if I have been infected with HSV-1 instead?
No, this test specifically detects HSV-2 DNA. If you suspect HSV-1 infection, a different test would be needed. Both viruses can cause similar symptoms, so your healthcare provider may recommend additional testing if needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy