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Herpes Simplex Virus Type 2 DNA Detection by Nucleic Acid Amplification (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of the herpes simplex virus type 2 (HSV-2) genetic material in your blood or plasma. It helps determine if you have an active infection or have been exposed to the virus.

Quick summary

["This test helps diagnose HSV-2 infections, which can affect the skin, mouth, or genitals."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
86541-0
Short code
HSV2 DNA Tiss Ql NAA+probe
Synonyms
HSV2 DNA Tiss Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Your doctor may order this test to help find out whether a certain condition or infection is present in your body. The results give your care team important information about how your body is working and help guide decisions about your diagnosis and treatment plan.

Your healthcare provider may recommend this test if you have symptoms like sores, pain, or unusual discharge in the genital or anal area. It may also be used if you have a history of HSV-2, unexplained genital ulcers, or if you are sexually active with multiple partners. Sometimes, it is done as part of a routine check-up for sexually transmitted infections (STIs).

Before your test, your healthcare provider will explain the procedure and give you specific instructions. You may be asked to avoid eating or drinking for several hours, stop taking certain medicines, or limit your activity beforehand. Tell your provider about any allergies, prescriptions, or supplements you take, and ask questions if anything is unclear.

No special preparation is needed for this test. You may have a blood sample drawn from a vein in your arm, similar to other blood tests. If you are concerned about discomfort, let your healthcare provider know. Avoid alcohol or certain medications that might affect test results if instructed by your provider.

Your results will show whether the substance being measured falls within the normal range. A normal result usually means there is no sign of the condition being tested for, while an abnormal result may point to a problem that needs closer attention or further testing. Your provider will review the findings with you and explain what they mean for your overall health.

If the test is positive, it means the virus DNA is found in your blood or plasma, indicating an active HSV-2 infection. If negative, the virus DNA was not detected at the time of testing. Results can help guide treatment and management plans, such as antiviral medications.

This test works by detecting a specific substance in the sample collected from your body. The sample is sent to a laboratory, where trained technicians use special equipment and testing methods to measure it accurately. The laboratory then reports the findings to your provider, who interprets them together with your medical history, symptoms, and physical exam.

This test uses a technique called nucleic acid amplification (NAAT) to detect the genetic material of HSV-2. A small sample of your blood or plasma is taken and analyzed in a lab to identify the virus’s DNA. This method is highly sensitive and can detect even small amounts of the virus.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-2 DNA Test (Nucleic Acid Test)

Frequently asked questions

HSV-2 is a common sexually transmitted infection that can cause recurrent outbreaks of genital sores. Early detection through this test helps manage symptoms, reduce transmission risk, and prevent complications. It is also important for monitoring treatment effectiveness and managing chronic infections.
What does it mean if my test result comes back positive, and what should I do next?
A positive result means the test detected the genetic material of HSV-2 in your blood or plasma, confirming an active infection. This does not necessarily mean you are currently experiencing symptoms. Your healthcare provider will discuss next steps, which may include antiviral treatment and managing outbreaks.
Can this test also be performed using other types of body fluid samples, such as saliva or urine?
No, this specific test is performed on blood or plasma samples. However, some healthcare providers may use similar nucleic acid amplification tests on other fluids like cerebrospinal fluid or genital secretions, depending on the clinical situation. Always ask your provider about the sample type used for your test.
The frequency of testing depends on your medical history, symptoms, and healthcare provider’s recommendations. If you have an active HSV-2 infection, your provider may recommend regular monitoring. If you are asymptomatic, testing may be done less frequently, such as during follow-up visits or if symptoms recur.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy