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Herpes Simplex Virus Type 2 DNA (Serum/Plasma) Qualitative Probe-Based Assay

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of genetic material from the herpes simplex virus type 2 (HSV-2) in your blood, which may indicate an active infection.

Quick summary

["The test helps determine if you have HSV-2, a virus that can cause genital herpes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
90454-0
Short code
HSV2 DNA Upper resp Ql NAA+probe
Synonyms
HSV2 DNA Upper resp Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like sores, itching, or unusual discharge in the genital area, or if you have a history of genital herpes. It can also be used to confirm a diagnosis in cases where symptoms are unclear or if you have recurrent outbreaks.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood sample drawn from a vein in your arm, similar to other blood tests. If you are taking blood thinners, let your provider know before the test.

What the Test Results Mean

A positive result means your blood contains genetic material from HSV-2, suggesting an active infection. A negative result means the virus was not detected in this sample. Results should be interpreted by your healthcare provider in the context of your medical history and symptoms.

How the Test Works

This test uses a molecular method to detect the DNA of HSV-2. A small sample of your blood (serum or plasma) is analyzed to identify the virus’s genetic material, which helps confirm an infection even when symptoms are not present.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is crucial for diagnosing HSV-2 infections, which can cause recurrent genital herpes. Early detection allows for appropriate treatment to manage symptoms, reduce transmission risk, and prevent complications. It can also help monitor the effectiveness of antiviral therapy.

Short name

HSV-2 DNA Test (Serum/Plasma)

Frequently asked questions

What does a positive result mean?
A positive result indicates that the genetic material of HSV-2 was found in your blood sample, suggesting you have an active HSV-2 infection. This does not necessarily mean you are experiencing symptoms at the moment, but it confirms the presence of the virus.
Can this test be used to detect past infections?
This test specifically looks for active HSV-2 DNA in your blood. To detect past infections, other tests (like antibody tests) are typically used, which measure your immune system’s response to the virus.
How often should I get this test?
The frequency of testing depends on your medical needs and healthcare provider’s recommendations. If you have recurrent outbreaks or specific risk factors, your provider may suggest regular testing to monitor your infection status.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy