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Herpes Simplex Virus Type 2 DNA (Genomic) Quantitative, Nucleic Acid Amplification Probe

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of genetic material from herpes simplex virus type 2 (HSV-2), which causes genital herpes. It helps determine if you have an active infection or have been exposed recently.

Quick summary

["This test can help diagnose genital herpes caused by HSV-2 and guide treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50663-4
Short code
HSV2 DNA # Ur NAA+probe
Synonyms
HSV2 DNA # Ur NAA+probe
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like sores, itching, or unusual discharge in the genital area, or if you’ve been diagnosed with genital herpes and want to confirm the type of virus causing it. They might also order it if you’re at risk of transmission or for monitoring during pregnancy.

How the Test Works

The test uses a specialized laboratory technique to identify tiny pieces of the virus’s DNA from a sample of your bodily fluid, such as saliva or swab from affected areas. This helps confirm whether HSV-2 is present in your body.

Sample Collection and Preparation

You’ll provide a sample, often collected via a swab of sores or saliva. The sample is then sent to a lab where it undergoes a process called nucleic acid amplification to detect the virus’s genetic material.

What to Expect Before the Test

If a swab is used, you may experience mild discomfort, but it’s quick. If saliva is collected, no preparation is needed beyond providing a sample when you’re not experiencing symptoms. Avoid cleaning the area with alcohol or harsh products before testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-2 DNA Test

Frequently asked questions

What Does a Positive Result Mean?
A positive result indicates the presence of HSV-2 DNA, meaning you likely have an active infection or have been recently exposed. This doesn’t mean you’ll always have symptoms, but it’s important to discuss treatment options with your healthcare provider.
What Does a Negative Result Mean?
A negative result means the test did not detect HSV-2 DNA in your sample at the time of testing. However, HSV-2 can sometimes be hard to detect, especially if symptoms are mild or absent. Your provider may recommend retesting or other tests if needed.
How Often Should I Get Retested?
If you have symptoms of genital herpes, retesting may be recommended if initial results are unclear or if symptoms persist. If you’re pregnant or planning pregnancy, your provider may advise retesting during different trimesters to monitor the infection.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy