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Herpes Simplex Virus Type 2 DNA Quantitative Polymerase Chain Reaction (PCR) in Plasma

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of genetic material from the herpes simplex virus type 2 (HSV-2), which causes genital herpes, in your blood plasma. It helps determine if you have an active infection.

Quick summary

["This test helps diagnose active genital herpes caused by HSV-2 and guides treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
103181-4
Short code
HSV2 DNA Ur Ql NAA+probe
Synonyms
HSV2 DNA Ur Ql NAA+probe
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like sores, pain, or unusual discharge in the genital area, or if you have recurrent outbreaks. It may also be used to confirm a diagnosis in people with suspected genital herpes, especially if other tests are inconclusive.

What to Expect Before the Test

No special preparation is needed. You may have a blood sample drawn from a vein in your arm, similar to other blood tests. The sample is collected in a plasma tube and sent to a lab for analysis.

What the Test Results Mean

A positive result means genetic material from HSV-2 was found in your plasma, indicating an active infection. A negative result means no detectable HSV-2 DNA was found at the time of testing. Results can vary depending on the stage of infection.

How the Test Works

This test uses a specialized molecular technique called polymerase chain reaction (PCR) to identify tiny amounts of HSV-2 DNA in your plasma. PCR amplifies and detects genetic material, making it possible to identify the virus even when it is present in very small quantities.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-2 DNA PCR (Plasma)

Frequently asked questions

What does a positive result mean?
A positive result indicates that the genetic material of HSV-2 was found in your blood plasma, suggesting an active infection with herpes simplex virus type 2. This means you may have an ongoing herpes outbreak or chronic infection. Your healthcare provider will discuss next steps, such as treatment options or further testing.
Can this test detect HSV-2 in other body fluids?
This test specifically looks for HSV-2 DNA in plasma. While HSV-2 can be detected in other fluids like saliva or genital secretions through different tests, this test is focused on blood plasma and is primarily used for diagnosing active infection.
How often should I get this test if I have recurrent outbreaks?
If you have recurrent genital herpes, your healthcare provider may recommend periodic testing to monitor your infection status or response to treatment. The frequency depends on your symptoms, treatment plan, and overall health. Regular follow-ups with your provider will help determine the best approach.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy